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Mediation model for the association between CRP and anhedonia at 6-month follow-up, with neural response to reward outcome > neutral outcome as mediator. Age, biological sex, and BMI percentile were included as covariates. A single model was computed which included all 3 clusters associated with task effects for this contrast as mediators (rACC/mPFC, right VS, left Caudate Head). CRP: C-reactive protein. CES-D: Center for Epidemiologic Studies- Depression Scale. BMI: Body Mass Index. rACC: rostral Anterior Cingulate Cortex. mPFC: medial Prefrontal Cortex.

Journal: Brain, Behavior, & Immunity - Health

Article Title: Neural response to reward as a potential pathway from inflammation to anhedonia in adolescents at risk for depression

doi: 10.1016/j.bbih.2026.101246

Figure Lengend Snippet: Mediation model for the association between CRP and anhedonia at 6-month follow-up, with neural response to reward outcome > neutral outcome as mediator. Age, biological sex, and BMI percentile were included as covariates. A single model was computed which included all 3 clusters associated with task effects for this contrast as mediators (rACC/mPFC, right VS, left Caudate Head). CRP: C-reactive protein. CES-D: Center for Epidemiologic Studies- Depression Scale. BMI: Body Mass Index. rACC: rostral Anterior Cingulate Cortex. mPFC: medial Prefrontal Cortex.

Article Snippet: C-Reactive Protein (hsCRP) ELISA from ALPCO was used to measure CRP.

Techniques:

– LME results for the MDD outcome across pro-inflammatory (Pro-Inf) and CRP main effects . MDD = Major depressive disorder; Fruit/Veg = Fruit/Vegetable intake; DepMed = Depression medication use; Pro-Inf = pro-inflammatory; CRP = C-reactive protein; B = regression weight; SE = standard error. Blue = positive value; Orange = negative value; ∗ = p < 0.05. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Journal: Brain, Behavior, & Immunity - Health

Article Title: Inflammation, mental health, and alcohol behaviors: Testing links leveraging a familial community sample

doi: 10.1016/j.bbih.2026.101229

Figure Lengend Snippet: – LME results for the MDD outcome across pro-inflammatory (Pro-Inf) and CRP main effects . MDD = Major depressive disorder; Fruit/Veg = Fruit/Vegetable intake; DepMed = Depression medication use; Pro-Inf = pro-inflammatory; CRP = C-reactive protein; B = regression weight; SE = standard error. Blue = positive value; Orange = negative value; ∗ = p < 0.05. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: Each plasma sample was assayed in triplicate using a multiplex of pro- and anti-inflammatory cytokines (Quanterix Human Cytokine 10 Plex Array) or C-reactive protein (CRP; R&D Systems Quantikine QuicKit ELISA).

Techniques:

LME results for the pro-inflammatory and CRP outcomes and alcohol use main effects. AlcQ = Alcohol quantity; AlcF = Alcohol frequency; F∗Q = Alcohol frequency∗alcohol quantity; AUD = Alcohol use disorder; Fruit/Veg = Fruit/Vegetable intake; DepMed = Depression medication use; Pro-Inf = pro-inflammatory; CRP = C-reactive protein; B = regression weight; SE = standard error. Blue = positive value; Orange = negative value; ∗ = p < 0.05. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Journal: Brain, Behavior, & Immunity - Health

Article Title: Inflammation, mental health, and alcohol behaviors: Testing links leveraging a familial community sample

doi: 10.1016/j.bbih.2026.101229

Figure Lengend Snippet: LME results for the pro-inflammatory and CRP outcomes and alcohol use main effects. AlcQ = Alcohol quantity; AlcF = Alcohol frequency; F∗Q = Alcohol frequency∗alcohol quantity; AUD = Alcohol use disorder; Fruit/Veg = Fruit/Vegetable intake; DepMed = Depression medication use; Pro-Inf = pro-inflammatory; CRP = C-reactive protein; B = regression weight; SE = standard error. Blue = positive value; Orange = negative value; ∗ = p < 0.05. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: Each plasma sample was assayed in triplicate using a multiplex of pro- and anti-inflammatory cytokines (Quanterix Human Cytokine 10 Plex Array) or C-reactive protein (CRP; R&D Systems Quantikine QuicKit ELISA).

Techniques: